Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Forigerimod trifluoroacetate | 00-00-0 | 99.9% | C117H181N34O32PS·xC2HF3O2 | 5 MG
Forigerimod TFA is a 21-amino-acid peptide fragment supplied as the trifluoroacetate salt. It acts as a CD4 T-cell modulator and has been used in research on autophagy and autoimmune disorders, including systemic lupus erythematosus. Supplied as a powder with high listed purity, it is intended for research use in cellular and immunology studies.
- 21-amino-acid peptide, TFA salt
- High purity suitable for research (listed 99.88%)
- Soluble in DMSO and water at 100 mg/mL with sonication
- Powder storage: -80°C (2 years) or -20°C (1 year)
- In solvent storage: -80°C (6 months) or -20°C (1 month)
Medchemexpress LLC xStAx-VHLL TFA | 100.0% | 3231.89 | 5 MG
xStAx-VHLL TFA is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. It inhibits the Wnt/β-catenin signaling pathway. xStAx-VHLL TFA can also inhibit the proliferation of colon cancer cells and demonstrates anti-tumor activity.
- Induces β-catenin degradation in a dose-dependent manner in colorectal cancer cells in vitro
- Inhibits cell proliferation in vitro
- Inhibits Wnt/β-catenin signaling in HEK293T cells in vitro
- Shows antitumor activity in a mouse intestinal tumor model in vivo
- Reduces tumor number and active β-catenin protein levels in APC min/+ mice in vivo
Medchemexpress LLC Maurocalcine (TFA) | 95.1% | 3858.55 (free base) | 100 UG
Maurocalcine TFA is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. It induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. This product exhibits an apparent affinity of 14 nM for RyR2 and can be applied to in vivo cell tracking or other cell imaging techniques.
- Agonist of ryanodine receptor (RyR) channel types 1, 2 and 3
- Exhibits cellular permeability
- Induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM
- Exhibits an apparent affinity of 14 nM for RyR2
- Can be applied to in vivo cell tracking or other cell imaging techniques
Medchemexpress LLC Nangibotide TFA | 99.36% | 1457.46 | 1 MG
Nangibotide TFA (LR12 TFA) is a synthetic peptide and a TREM-1 receptor inhibitor. It inhibits NF-κB and NLRP3 inflammasome activation and reduces the release of pro-inflammatory factors such as IL-1β and IL-8. This peptide also inhibits apoptosis, reducing excessive inflammatory responses and protecting tissues from damage. It can be used in research for myocardial ischemia-reperfusion injury, septic shock, acute lung injury, osteoarthritis, and acute liver failure.
- Inhibits NF-κB and NLRP3 inflammasome activation
- Reduces release of pro-inflammatory factors like IL-1β and IL-8
- Protects tissues (liver, lung) from damage
- Can be used in research for various inflammatory and injury conditions
Medchemexpress LLC APL180 TFA | 98.8% | 2310.60 (free base) | 5 MG
APL180 TFA (L-4F) is an apolipoprotein AI mimetic peptide. It enhances the anti-inflammatory activity of high-density lipoprotein (HDL) and is utilized in the study of cardiovascular diseases.
- Enhances anti-inflammatory activity of high-density lipoprotein (HDL)
- Useful in cardiovascular disease research
- Purity: 98.8%
- Molecular weight: 2310.60 (free base)
- Soluble in DMSO and various in vivo dissolution protocols
Medchemexpress LLC Mal-PEG2-NH2 TFA | 660843-23-2 | 99.4% | 342.27 | 50 MG
Mal-PEG2-NH2 (TFA) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase and a ligand for the target protein via a linker. The product appears as an oil, light yellow to yellow in color. This product is for research use only and not intended for patient use.
- PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Exploits the ubiquitin-proteasome system for selective protein degradation.
- Appears as an oil, light yellow to yellow in color.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid puriss. p.a., for HPLC, 99.0 (GC), 76-05-1, MFCD00004169
Trifluoroacetic acid puriss. p.a., for HPLC, 99.0 (GC)
Medchemexpress LLC Bibo 3304 trifluoroacetate | 191868-14-1 | MFCD04112989 | 100.0% | 643.66 g/mol | C31H36F3N7O5 | 5 MG
BIBO3304 (trifluoroacetate) is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist used as a research tool to probe NPY1R-mediated signaling in pharmacology and neuroscience studies. It is supplied as a high-purity solid and is characterized for receptor binding and in vitro functional assays.
- High potency and selectivity for the NPY Y1 receptor.
- Suitable for in vitro receptor binding and functional assays.
- High reported purity for reproducible experimental results.
- Available as a solid and as a DMSO solution for assay convenience.
- Well characterized with supporting chemical identifiers and structural data.
Hampton Research 50% W/V POLYETHYLENE GL 200ML
HR2-607/50% w/v Polyethylene glycol 10,000 - 200 ml. Please note items from this supplier are non-returnable.
Hampton Research 30% W/V POLYETHYLENE GL 200ML
HR2-609/30% w/v Polyethylene glycol 20,000 - 200 ml. Please note items from this supplier are non-returnable.
Medchemexpress LLC TP-5801 TFA | 99.6% | 641.48 | 5 MG
TP-5801 TFA is an orally active TNK1 (non-receptor tyrosine kinase) inhibitor with anti-tumor activity.
- TNK1 inhibitor with an IC50 of 1.40 nM.
- Inhibits TNK1-driven, BCR-ABL-driven and IL-3-driven Ba/F3 cell growth.
- Inhibits TNK1-dependent L540 cell growth.
- Demonstrates efficacy in mouse survival models.
- Capable of inhibiting localized tumor growth in vivo.
- For research use only.
Medchemexpress LLC Eda-da tfa | 87156-01-2 | 95.0% | 298.22 | 5 MG
EDA-DA is a N-terminally tagged dipeptide probe used to label Peptidoglycan (PG) of bacteria. It functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- N-terminally tagged dipeptide probe
- Labels peptidoglycan of bacteria
- Click chemistry reagent with an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Charybdotoxin (TFA) | 96.8% | 4295.89 | 1 MG
Charybdotoxin (TFA) | 96.8% | 4295.89 | 1 MG
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic anhydride | 407-25-0 | MFCD00000416 | 500g
Trifluoroacetic anhydride | Purity: ≥99% | MW:210.03 | 407-25-0 | MFCD00000416 | 500g