Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Gln-AMS TFA | 209543-57-7 | >99.85% | 588.47 | 1 MG
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. It inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM. It is for research use only.
- Type Ia aminoacyl-tRNA synthetase (AARS) inhibitor
- Inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM
Medchemexpress LLC KRFK TFA | 99.8% | 577.73 | 25 MG
KRFK TFA is a peptide derived from TSP-1 that can activate TGF-β. It promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. This product can be used for research on chronic ocular surface inflammatory disorders.
- Activates TGF-β
- Promotes TGF-β-mediated signaling
- Independent of thrombospondin (TSP) receptors
- Suitable for research on chronic ocular surface inflammatory disorders
Medchemexpress LLC Valylleucine TFA (Val-Leu TFA) | 27530-02-5 | 99.3% | 344.33 | 5 MG
Valylleucine TFA is a polypeptide identified through peptide screening. Peptide screening serves as a research tool, primarily utilizing immunoassay to pool active peptides. This process is useful for studying protein interaction, functional analysis, and epitope screening, particularly in the development of agents.
- Identified through peptide screening
- Research tool primarily using immunoassay to pool active peptides
- Useful for studying protein interaction, functional analysis, and epitope screening
- Solutions should be aliquoted and stored to prevent inactivation from repeated freeze-thaw cycles
- If water is used as stock solution, dilute to working solution, then filter and sterilize with a 0.22 μm filter before use
Medchemexpress LLC UNC4976 trifluoroacetate | 98.0% | 961.12 g/mol | C49H71F3N6O10 | 5 MG
UNC4976 TFA is the trifluoroacetate salt of UNC4976, a peptidomimetic positive allosteric modulator (PAM) of the CBX7 chromodomain that modulates chromodomain-nucleic acid interactions. It is supplied as a purified research compound intended for in vitro studies in epigenetics and chromatin biology.
- Trifluoroacetate salt form for improved handling and stability.
- High purity suitable for research applications (98.0%).
- Molecular formula C49H71F3N6O10 and molecular weight 961.12 g/mol.
- Available in small pack sizes for screening and assay development.
- Suitable for use in studies of chromodomain function and epigenetic modulation.
- Provided with documentation specifying identity and purity.
Medchemexpress LLC KRpep-2d TFA | 2098181-84-9 | 95.09% | 2675.03 | 25 MG
KRpep-2d TFA is a potent K-Ras inhibitor that inhibits the proliferation of K-Ras-driven cancer cells. It possesses a cyclic structure, with specific amino acid residues (Leu77, Ile9, and Asp12) being critical for its K-Ras inhibitory activity. This peptide can be used for cancer research.
- Potent K-Ras inhibitor
- Inhibits proliferation of K-Ras-driven cancer cells
- Cyclic structure important for inhibitory activity
- Demonstrates inhibitory activity in A427 cells
- Targets Ras
- Involved in GPCR/G Protein and MAPK/ERK Pathway
Medchemexpress LLC Ezm0414 Tfa | 2411759-92-5 | 95.5% | 514.51 | 25 MG
EZM0414 TFA is the trifluoroacetate salt form of EZM0414. It functions as a potent, selective, and orally active inhibitor of SETD2, making it suitable for research applications. This compound is being investigated for its potential in treating relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma.
- TFA salt form of EZM0414.
- Potent, selective, orally active SETD2 inhibitor.
- IC50 of 18 nM in biochemical assay.
- IC50 of 34 nM in cellular assay.
- Appearance is solid, white to light yellow.
- Store at 4°C, sealed, away from moisture.
- When in solvent, store at -80°C for 2 years or -20°C for 1 year, sealed and away from moisture.
Medchemexpress LLC 6bK TFA | 1774353-12-6 | 99.68% | 871.94 | 1 ML
6bK TFA is a potent and selective insulin degrading enzyme (IDE) inhibitor with an IC50 value of 50 nM. It has been shown to increase circulating insulin in high-fat-fed mice. Acute administration of 6bK TFA enhances glucose tolerance to oral glucose, particularly in high-fat-fed mice. This compound is suitable for use in type 2 diabetes research. It is intended for research use only and is not sold to patients.
- Potent and selective insulin degrading enzyme (IDE) inhibitor with an IC50 value of 50 nM.
- Increases circulating insulin in high-fat-fed mice.
- Enhances glucose tolerance to oral glucose.
- Suitable for use in type 2 diabetes research.
- Intended for research use only.
Medchemexpress LLC VTP-27999 TFA | 1013937-63-7 | 97.00% | C28H42ClF3N4O7 | 25 MG
VTP-27999 TFA is a potent alkyl amine Renin inhibitor, recognized for its role in addressing hypertension and related end-organ diseases. This compound is primarily utilized in research settings to explore the mechanisms of renin-angiotensin-aldosterone system (RAAS) regulation. Its specific inhibitory action offers a valuable tool for studying cardiovascular conditions and developing novel therapeutic strategies.
- Potent alkyl amine renin inhibitor
- Useful for hypertension research
- Applicable in studies of end-organ diseases
- Supports research on RAAS regulation
- Aids in the development of cardiovascular therapies
Medchemexpress LLC Peptide R (TFA) | 98.3% | 900.08 (free base) | 1 MG
Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It shows outstanding capacities to remodel the tumor stroma and can be used for solid tumor (glioblastoma, etc.) research.
- Synthetic and specific CXCR4 antagonist
- Remodels tumor stroma
- Used for solid tumor research (glioblastoma, etc.)
- Supports cancer immunotherapy
- Supports cancer metabolism and metastasis research
- Relevant to immunology and inflammation
- Relevant to GPCR/G protein studies
- Exhibits anti-cancer properties
- Modulates microglia reactivity
- Influences self-renewal mechanisms
- Supports angiogenesis research
- Acts as an inhibitor
Medchemexpress LLC Gallinamide A TFA | 1352920-57-0 | 706.79 | 1 MG
Gallinamide A TFA is a linearly depositing peptide and a potent inhibitor of cathepsin L (CatL) with an IC50 of 17.6 pM. It inhibits SARS-CoV-2 infection by inhibiting CatL (EC50: 28 nM) and also inhibits Plasmodium falciparum (IC50: 50 nM). It is for research use only and not sold to patients.
- Inhibits cathepsin L, B, V, K, and S.
- Effective against SARS-CoV-2 infection.
- Inhibits P. falciparum.
- Exhibits low cytotoxicity in VeroE6 cells.
- Shows synergistic effects with TMPRSS2 inhibitor Nafamostat.
Medchemexpress LLC Glycyl-Exatecan (TFA) | 1883333-57-0 | 96.9% | 25 MG
Glycyl-Exatecan TFA (Glycyl-DX-8951 TFA) is an anticancer agent and a derivative of Exatecan. It exhibits significant antitumor activity and is suitable for research on various cancers, including solid tumors.
- Derivative of Exatecan
- Anticancer agent
- Exhibits significant antitumor activity
- Suitable for research on various cancers
- Can be used for solid tumors research
