Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC FLAG peptide TFA | 99.6% | 1012.97 | 5 MG
FLAG peptide TFA is the trifluoroacetic acid salt form of FLAG peptide, often denoted as HY-P0223. It functions as a versatile fusion tag specifically designed for the purification of recombinant proteins. This peptide plays a crucial role in maintaining the natural, functional folding of the proteins it is fused with, ensuring their biological activity. It can be efficiently removed by enterokinase and is capable of being eluted under non-denaturing conditions, which is beneficial for preserving protein integrity.
- Multifunctional fusion tag
- Used for purification of recombinant proteins
- Maintains natural folding of fusing proteins
- Can be removed by enterokinase
- Eluted under non-denaturing conditions
Hampton Research 50% W/V POLYETHYLENE GL 200ML
HR2-607/50% w/v Polyethylene glycol 10,000 - 200 ml. Please note items from this supplier are non-returnable.
Hampton Research 30% W/V POLYETHYLENE GL 200ML
HR2-609/30% w/v Polyethylene glycol 20,000 - 200 ml. Please note items from this supplier are non-returnable.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic anhydride | 407-25-0 | MFCD00000416 | 500g
Trifluoroacetic anhydride | Purity: ≥99% | MW:210.03 | 407-25-0 | MFCD00000416 | 500g
Medchemexpress LLC Nangibotide TFA | 99.36% | 1457.46 | 1 MG
Nangibotide TFA (LR12 TFA) is a synthetic peptide and a TREM-1 receptor inhibitor. It inhibits NF-κB and NLRP3 inflammasome activation and reduces the release of pro-inflammatory factors such as IL-1β and IL-8. This peptide also inhibits apoptosis, reducing excessive inflammatory responses and protecting tissues from damage. It can be used in research for myocardial ischemia-reperfusion injury, septic shock, acute lung injury, osteoarthritis, and acute liver failure.
- Inhibits NF-κB and NLRP3 inflammasome activation
- Reduces release of pro-inflammatory factors like IL-1β and IL-8
- Protects tissues (liver, lung) from damage
- Can be used in research for various inflammatory and injury conditions
Medchemexpress LLC Maurocalcine (TFA) | 95.1% | 3858.55 (free base) | 100 UG
Maurocalcine TFA is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. It induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. This product exhibits an apparent affinity of 14 nM for RyR2 and can be applied to in vivo cell tracking or other cell imaging techniques.
- Agonist of ryanodine receptor (RyR) channel types 1, 2 and 3
- Exhibits cellular permeability
- Induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM
- Exhibits an apparent affinity of 14 nM for RyR2
- Can be applied to in vivo cell tracking or other cell imaging techniques
Medchemexpress LLC Mal-PEG2-NH2 TFA | 660843-23-2 | 99.4% | 342.27 | 50 MG
Mal-PEG2-NH2 (TFA) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase and a ligand for the target protein via a linker. The product appears as an oil, light yellow to yellow in color. This product is for research use only and not intended for patient use.
- PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Exploits the ubiquitin-proteasome system for selective protein degradation.
- Appears as an oil, light yellow to yellow in color.
Medchemexpress LLC VTP-27999 (TFA) | 1013937-63-7 | 97.0% | C28H42ClF3N4O7 | 5 MG
VTP-27999 (TFA) is an alkyl amine Renin inhibitor useful for hypertension and end-organ diseases. This product is for research use only.
- Alkyl amine Renin inhibitor
- Useful for hypertension research
- Useful for end-organ diseases research
- For research use only
Medchemexpress LLC TP-5801 TFA | 99.6% | 641.48 | 5 MG
TP-5801 TFA is an orally active TNK1 (non-receptor tyrosine kinase) inhibitor with anti-tumor activity.
- TNK1 inhibitor with an IC50 of 1.40 nM.
- Inhibits TNK1-driven, BCR-ABL-driven and IL-3-driven Ba/F3 cell growth.
- Inhibits TNK1-dependent L540 cell growth.
- Demonstrates efficacy in mouse survival models.
- Capable of inhibiting localized tumor growth in vivo.
- For research use only.
Medchemexpress LLC JBJ-09-063 TFA | 99.6% | 670.67 | 5 MG
JBJ-09-063 TFA is a mutant-selective allosteric EGFR inhibitor with IC50s of 0.147 nM, 0.063 nM, 0.083 nM and 0.396 nM for EGFR L858R, EGFR L858R/T790M, EGFR L858R/T790M/C797S and EGFRLT/L747S. It effectively reduces EGFR, Akt and ERK1/2 phosphorylation and is effective across EGFR tyrosine kinase inhibitor (TKI)-sensitive and resistant models. JBJ-09-063 TFA can be used for researching EGFR-mutant lung cancer.
- Effectively inhibits cell growth and increases apoptosis, even in gefitinib-resistant H3255GR cells with an EGFR T790M mutation.
- Shows efficacy in H1975 cells expressing osimertinib-resistant mutations.
- Exhibits IC50s of 50 nM and 6 nM in Ba/F3 cell when used alone or in combination.
- Has favorable pharmacokinetic properties and good efficacy upon oral dosing.
Medchemexpress LLC Goralatide TFA | 1796568-94-9 | 98.0% | 1 MG
Goralatide TFA is an inhibitor of cell cycle progression that enhances the selectivity of hyperthermic purging of human progenitor cells. It has potential for research related to leukemia.
- Inhibits cell cycle progression.
- Enhances selectivity of hyperthermic purging of human progenitor cells.
- Potential for leukemia research.
Medchemexpress LLC Ac-VEID-CHO (trifluoroacetate salt) | 00-00-0 | 99.8% | 614.57 Da | C24H37F3N4O11 | 1 MG
Ac-VEID-CHO (TFA) is a peptide-derived reversible caspase inhibitor intended for in vitro research into apoptosis and neurodegenerative pathways. It is supplied as a trifluoroacetate salt and demonstrates potent inhibition of several executioner caspases in biochemical assays. Not for human or clinical use.
- Reversible caspase inhibitor targeting caspase-6, caspase-3, and caspase-7.
- Reported IC50 values in the low nanomolar range for primary targets.
- High purity suitable for biochemical assays (99.8%).
- Available in small mg-scale quantities for research use.
- Limited cellular activity due to poor cellular accumulation.
Medchemexpress LLC NCGC00138783 TFA | 99.4% | C28H27F4N7O3S | 25 MG
NCGC00138783 TFA is a selective inhibitor targeting the CD47/SIRPα axis, directly blocking the interaction between the CD47 and SIRPα axis with an IC50 of 50 μM.
- Appearance: Solid
- Color: White to light yellow
- Molecular weight: 617.62
Medchemexpress LLC Ala-MPSD TFA | 98.02% | 3016.76 | 5 MG
Ala-MPSD TFA is a control peptide for MPSD (HY-P10471). In Ala-MPSD TFA, the four serine residues of MPSD are substituted by alanines.
- Control peptide for MPSD (HY-P10471)
- Four serine residues of MPSD are substituted by alanines
- Molecular formula: C147H243N41O27.XC2HF3O2
- Sequence: Lys-Lys-Lys-Lys-Lys-Arg-Phe-Ala-Phe-Lys-Lys-Ala-Phe-Lys-Leu-Ala-Gly-Phe-Ala-Phe-Lys-Lys-Asn-Lys-Lys
- Purity: 98.02% (HPLC)
- Appearance: White to off-white (solid)
- MS consistent with structure